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It should be noted that while the HIF pathway can induce antioxidant genes like SOD2 to maintain adaptive balance under acute hypoxia, this protective effect in chronic diseases like cancer may conversely aid malignant cells in resisting apoptosis, constituting another dimension of intervention complexity [501]

Answer-first: topical peptides can modestly improve overall skin texture and support collagen, but no peptide is a proven cure for established acne scars, and the injectable ones marketed for scars lack human evidence for this use

Researchers examine healing rates in controlled injury models

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