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Challenges comprise of standardized assessment of treatment outcomes, antioxidant selection and dosage issues, and ongoing observation and evaluation of long-term effects
The study found that the effect of melatonin was not due to the melatonin receptors but rather acts in a receptor-independent manner to clear amyloid-beta plaque.[ref] In addition to clearing amyloid-beta plaque, another way that melatonin can protect against Alzheimers is through the reduction of ROS in the mitochondria in brain cells.[ref] This may be the key, rather than amyloid-beta clearance
They include a wide range of compounds such as fungicides, plasticizers, pesticides and industrial chemicals, among others (89)
2018, doi:10.3390/nu10091203 Combs, Gerald F Jr
