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The pace may slow after the first month as melanin levels stabilize

This improvement was associated with a modulation of the endoplasmic reticulum (ER) stress response, reflected in suppressed levels of C/EBP homologous transcription factor protein (CHOP), a proapoptotic factor, and increased expression of glucose regulatory protein 78, a chaperone protecting against ER stress

This may help lighten the skin and improve its texture and color since it may hinder melanin synthesis, which leads to dark patches

Clinical effectiveness and predictors of response to topiramate plus lifestyle modification in youth with obesity seen in a weight management clinical setting