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Injection site rotation: Move sites week to week (abdomen, thighs, upper arms), keeping each shot at least 1 inch from the last to limit irritation and prevent lipohypertrophy [15]
Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses
Maintenance protocols typically use lower doses than initial loading phases
Draw the prescribed dose into a U-100 insulin syringe (e.g., 500 IU = 20 units) and tap out any air bubbles
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