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Tesamorelin has a more established evidence base, primarily in the context of HIV-associated lipodystrophy, where pivotal randomised controlled trials (including Falutz et al., NEJM, 2010) demonstrated statistically significant reductions in visceral adipose tissue
Safety: No toxic dose has been determined to date Study in rats with a single 20mg/kg IM dose, no deaths, abnormalities in body weight, food intake, or behavior noted Study in dogs at 10mg/kg IM showed no adverse effects Study in rats of 28 days of 0.2 mg, 1mg, or 4mg/day IM no changes relative to saline injection Study in dogs of 0.1 mg, 0.5 mg, or 2 mg/day IM no changes relative to saline injection Uses: Study: protection against NSAID and alcohol adverse effects Study: healing actions on wound and injuries from trauma and systemic issues Study: benefits in neuropsychiatric conditions like depression, though other studies show it has poor penetration of the blood brain barrier
Consistent with observations in Fig
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