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Concomitantly, the increased levels of insulin reduce the binding of liver sex hormone binding globulin SHBG to testosterone, leading to hyperandrogenism (153)
Tirzepatide, currently recognized as the most effective dual-agonist therapy, targets GLP-1 and GIP receptors but lacks the glucagon component that enhances retatrutide's metabolic impact
doi: 10.1093/humrep/12.6.1142 25 van VugtDA
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