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P = .002)
47 Another approach is PEGylating which may destroy the activity in vitro but retain the efficacy in vivo
Additionally, it has been demonstrated that also chronic hepatitis C virus (HCV) infection in hepatocyte cell lines led to a decreased levels of reduced GSH and a concomitant increase of oxidative stress ( The altered intracellular redox state has been envisaged as target for anti-influenza therapy, but also in this case the data arising from in vivo studies are inconsistent, and in some cases have indicated that antioxidants could exacerbate the disease
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