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The determination of the optimum dosages for a particular treatment is within the skill of the art

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Although numerous studies showed that oxidative stress plays a substantial role in motor neuron degeneration in ALS [1518, 95], some evidence points to oxidative stress as not just an event in the CNS but rather a systemic process leading to the suggestion that ALS is possibly a systemic disease [96]

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Accordingly, anti-inflammatory pharmaceuticals may be therapeutic in these conditions (Esser 2015)

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