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Molecular bases of incretin system Synthesis and distribution of GLP-1 GLP-1, GLP-2, and glucose-dependent insulinotropic polypeptide (GIP) are the predominant gut-derived incretin hormones that lead to postprandial insulin secretion in a glucose-dependent fashion
The activation of the Nrf2 (nuclear factor erythroid-derived 2)/ARE (antioxidant response elements) pathway is likely a principal and underlying mechanism of hormesis, which can limit age-related damage, numerous disease processes progression, and induction of toxicities due to chemicals and radiations (70)
While it may increase melanin production, its systemic activity on receptors raises safety and regulatory issues
The mechanism is linked to the regulation of gut microbiota and inhibition of LPS and TMAO-induced PI3K/AKT/NF-B signaling pathways
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