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Moreover, in various scientific domains, research findings are frequently presumed to reflect the prevailing bias (298), and a significant number of published results may be false or exaggerated (277, 278, 299301), with an estimated 85% of research resources being wasted (302)

As of today, though, no formal FDA rule has actually changed

Prog Polym Sci 32:933961 Patel TK, Adhikari N, Amin SA, Biswas S, Jha T, Ghosh B (2021) Small molecule drug conjugates (SMDCs): an emerging strategy for anticancer drug design and discovery

1000 ug Excipients : concentrated hydrochloric acid, sodium chloride, water for injection for a 2 ml ampoule