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The fluorescence intensity was measured to quantify the concentration of GSH at ex = 365 nm
A phase 2 trial showed that PTX improved hepatic histological features, including fibrosis, in patients with MASH (NCT00590161)
However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)
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