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Indeed, homocysteine neurotoxic properties have been attributed to NMDA receptor stimulation, auto-oxidation elevating oxidative stress, mitochondrial complex I inhibition, and allosteric D2 receptor antagonism (88)

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In a clinical trial in pediatric patients aged 12 years and older with normal baseline heart rate, more patients treated with this drug compared to placebo had maximum changes in heart rate of 20 bpm or more (54% vs 39%)

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