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Pulmonary hypertension, on the other hand, can appear not just with shortness of breath but with these other fatigue chest pain high heart rate (tachycardia) pain in the upper abdomen loss of appetite coughing wheezing lightheadedness loss of consciousness leg swelling If shortness of breath appears alongside general high blood pressure, there are likely other issues that are contributing to this symptom, such as: heart disease angina heart attack heart failure kidney disease stroke anxiety or panic attacks You can also have shortness of breath because of conditions unrelated to your blood pressure measurement, like asthma, pneumonia, or chronic obstructive pulmonary disease (COPD)