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Another difficulty associated with vaccination against viruses targeting the upper respiratory tract is the generation of long-lasting mucosal immunity

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Clinical data shows benefits fade within 2-6 months despite maintenance therapy, with only 6.2% of patients retaining any effect at 6 months in the Zubair et al

Francque S, Verrijken A, Caron S, Prawitt J, Paumelle R, Derudas B, Lefebvre P, Taskinen MR, Van Hul W, Mertens I, Hubens G, Van Marck E, Michielsen P, Van Gaal L, Staels B (2015) PPARalpha gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis