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Some of these include severe gastrointestinal issues (nausea, vomiting, diarrhea), pancreatitis, rapid weight loss, severe abdominal pain, and symptoms of thyroid cancer (such as a lump or swelling in the neck, trouble swallowing, or voice changes)

However, Sofer said that one large study has been published showing that the use of semaglutide decreased complications and death for patients with a background of ischemic heart disease and cardiovascular disease

The problem of discontinuation of the drugs is big, since there are limited data and the likelihood is that the weight will be regained unless there are substantial changes in lifestyle