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These symptoms often subside as the body adjusts to the medication
The SURPASS-4 trial (Del Prato et al., Lancet , 2021) included patients with eGFR as low as 30 and found no need for dose adjustment, but titration was slower (6-week intervals instead of 4-week)
supplemented LC individually (50 g/day/cow), as discussed earlier, as well as with choline chloride (60 g/day/cow) on SCC and reproductive indices of Holstein dairy cattle
Stets R, Popescu M, Gonong JR, Mitha I, Nseir W, Madej A, Kirsch C, Das AF, Garrity-Ryan L, Steenbergen JN, Manley A, Eckburg PB, Tzanis E, McGovern PC, Loh E
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