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However, under pathological conditions, activated MMPs are associated with increased degradation of ECM components and are involved in ECM re-modeling (Dollery et al., 40 oligomers can increase MMP-2 activity in stimulated astrocytes and correlated with increased oxidative stress, inflammation and reduced cell viability

As a result the response function of a metabolite or a reaction velocity to changes in a parameter or input may be nonlinear and non-monotone

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Ceriello A, Esposito K, Testa R, Bonfigli AR, Marra M, Giugliano D: The possible protective role of glucagon-like peptide 1 on endothelium during the meal and evidence for an endothelial resistance to glucagon-like peptide 1 in diabetes