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The functional significance of this redundancy is demonstrated by knockout studies: IL-17F expression is upregulated in Il17a -deficient mice (127), and dual Il17a/Il17f deficiency completely prevented CS-induced airspace enlargement after 24 weeks, whereas single Il17a knockout conferred only partial protection (114, 116)
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Smith LJ, Holbrook JT, Wise R, Blumenthal M, Dozor AJ, Mastronarde J, Williams L: Dietary intake of soy genistein is associated with lung function in patients with asthma
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