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We hypothesised that the reported brainstem transcriptomic changes might reflect modulation of NTS Ppg neuron activity downstream of GIPR antagonism in the hypothalamus and therefore tested the effect of GIPR-antag on mice with ablated NTS Ppg neurons (Ppg NTS-Abl ) generated by bilateral stereotactic injection of AAV-DTA into the NTS of Ppg-Cre or control mice (Cre-negative mice receiving AAV-DTA into the NTS) (Fig
Rotate the exact spot within the same area each session
At 10 percent concentration with the same application schedule, consumption rises to approximately 1.4 grams per month
What happens at very low doses At microdose levels (0.125 to 0.5 mg weekly), receptor activation is partial
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