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Biomaterials 29:44294438 Regina A, Demeule M, Tripathy S, Lord-Dufour S, Currie J-C, Iddir M, Annabi B, Castaigne J-P, Lachowicz JE (2015) ANG4043, a novel brain-penetrant peptidemAb conjugate, is efficacious against HER2-positive intracranial tumors in mice

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PEG-containing liposomes, with or without RSV, demonstrated high hemocompatibility, maintaining hemolysis below 4% at the highest concentration and below 1% at lower concentrations

At intermediate doses (310 g/kg/min) , -adrenergic receptor activation predominates, increasing myocardial contractility and HR, resulting in increased SBP with minimal change or a slight decrease in DBP and SVR