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Here is a list of potential side effects associated with metformin: Nausea Vomiting Diarrhea Abdominal discomfort or cramping Loss of appetite Lactic acidosis (a rare but serious side effect): weakness, unusual muscle pain, trouble breathing, dizziness, lightheadedness, fast or slow heart rate Vitamin B12 deficiency with long-term use Metallic taste in the mouth Hypoglycemia (low blood sugar), especially when used with other diabetes medications Skin reactions: rash, itching, redness Changes in taste perception Respiratory issues: shortness of breath Liver problems: elevated liver enzymes Individual reactions to metformin can vary, and not everyone will experience these side effects

Achieving significant weight loss often requires making changes to one's diet and exercise routine

Because retatrutide is studied as a once-weekly injection, the medicine may continue to have effects for a period after stopping

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