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It should be noted that: the numerical values given here are only examples, provided that the molar ratio of amino resin, Fmoc-Pro-OH, HOBt, DIC mixture is 1: 2-4: 2.2-4.4: 2.2-4.4 are all suitable for use in the present invention

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These observations were corroborated by single-cell calcium imaging studies in slices of arcuate nuclei, demonstrating that GLP-1MK-801 inhibits the NMDA-induced intracellular calcium surge relative to GLP-1 alone (Extended Data Fig

Cell culture and transfection HEK293T cells (ATCC, catalogue no