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This is due to the filler material expanding within the blood vessels

10.3390/ijms21103483 49 KranzP.NeumannF.WolfA.ClassenF.PompschM.OcklenburgT.et al (2017)

Greenwood-Van Meerveld and colleagues (2012, Journal of Experimental Pharmacology , PMC4863553) demonstrated in a rat model of postoperative ileus that ipamorelin significantly increased laparotomy-induced reduction of cumulative fecal pellet output, food intake, and body weight findings interpreted as prokinetic effects mediated through peripheral GHS-R1a in the enteric nervous system

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