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When qualitative data were identified in one of the review documents, the following data were extracted: qualitative data type (e.g., key opinion leader interviews, focus groups, cognitive interviews, or exit interviews), qualitative study objectives (e.g., to establish a PROs content validity, to evaluate treatment benefit), and FDA or EMA regulatory commentary regarding the submitted evidence or recommendations for future qualitative research
However, nausea is the most commonly reported adverse effect, with incidence varying by medication and dose: approximately 15-30% for most GLP-1 agonists and up to 30-44% at higher doses of semaglutide and tirzepatide according to FDA prescribing information
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