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From the 1950s to the 1990s, doctors prescribed amphetamines to decrease a patients appetite and help stimulate weight loss
Endocr J (2003) 50(3):2719.10.1507/endocrj.50.271 143 NguyenNQDebreceniTLBambrickJEChiaBWishartJDeaneAMet alAccelerated intestinal glucose absorption in morbidly obese humans: relationship to glucose transporters, incretin hormones, and glycemia
For GLP-1s, it costs $129 for the first month ($80 off), then $209 per month
So, yeah, I hold open the possibility it could be uniquely deleterious
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