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At 25M of menadione, there was a 13.3-fold increase for HEK-293 cells and 11.5-fold increase for K-562 cells in the amount of oxidized glutathione compared to the control
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The stability or even slight decrease in V4 (rate of uncoupled respiration) further supports the idea that DSIP may improve the state of the inner mitochondrial membrane by reducing proton leak
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