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Meanwhile, a separate study of 146,000+ adults on GLP-1 therapy showed elevated rates of bone-weakening conditions, tied to rapid weight loss without adequate protein, strength training, and nutritional support

WADA Prohibition The World Anti-Doping Agency has addressed MOTS-c in anti-doping guidance: While not explicitly listed by name in current prohibited substances lists, would likely fall under non-approved substances (Section S0) Detection methods under development for anti-doping testing programs Use by competitive athletes prohibited under WADA Code Exercise-mimetic properties create performance enhancement concerns USADA guidance specifically warns athletes that MOTS-c is not approved by FDA and remains prohibited for competitive sport use

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For individuals with a Body Mass Index (BMI) above the healthy range, embarking on a weight loss journey becomes particularly beneficial, especially when coupled with other health risk factors like high blood pressure, cholesterol, smoking, diabetes, sedentary lifestyle, and a personal/family history of heart disease