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Potential benefits: Extends beyond 30 days Convenient pre-measured doses Significant risks: Ice crystal formation can damage peptide structure Unknown potency loss during freezing/thawing No clinical data supporting this practice Recommendation: Not advised

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Am J Physiol Endocrinol Metab 294: E846-852, 2008

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Semaglutide is not contraindicated after cholecystectomy, but it requires individualized assessment because GLP-1 therapy slows gastric emptying, which may intensify bile-related digestive symptoms in some patients

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