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Alternatively, tirzepatide (a dual GIP/GLP-1 agonist) produces even more robust weight lossup to 22% in clinical trialsand may be considered for patients who have plateau on semaglutide alone

Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione [PMID: 12738715] Laboratory literature summary: Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies