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A conclusion in favor of the non-inferiority of sitagliptin to glipizide may be limited to patients with baseline A1C comparable to those included in the study (over 70% of patients had baseline A1C less than 8% and over 90% had A1C less than 9%)
These medications stimulate insulin release in response to meals, inhibit glucagon secretion, slow gastric emptying, and enhance satiety by acting on brain receptors, leading to improved blood sugar control and reduced appetite
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