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253 The first trial enrolled 234 participants (mean age 48 years) who were unwilling or unable to use positive airway pressure (PAP) therapy, and the second group consisted of 235 participants (mean age 52 years) who had been on consistent PAP therapy for at least three months prior to screening and were expected to continue therapy during the trial
Wegovy injection showed weight loss of 15% in its key trial, versus 2% for placebo, while Zepbound showed 21% on its highest dose, compared with 3% for those on placebo
Quick comparison: Injection: Once weekly FDA-approved 2021 Most long-term data Max dose 2.4 mg Pill: Once daily FDA-approved December 2025 ~16.6% average weight loss in trials No needles required Both forms require a prescription
For example, when youre losing body fat, theres a risk youll lose muscle at the same time
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