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It may also be prescribed off-label to help manage levels in those with prediabetes or as a weight loss drug, though off-label uses may or may not be covered by insurance
Unlike semaglutide, which mimics one receptor (GLP-1), retatrutide mimics three hormones - GLP-1, GIP, and glucagon
Frail elderly patients or those with multiple comorbidities, polypharmacy, or cognitive impairment may not be suitable candidates for weight loss injections
The reasons patients may prefer oral administration over the subcutaneous route are most often needle aversion and local skin reactions, wrote first author Sean Wharton, MD, an obesity specialist and medical director of the Wharton Medical Clinic, and colleagues
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