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Cross-trial context, not a head-to-head result Not comparable across rows: three separate trials, three entry criteria, three durations, and three estimands, so the gaps between these rows are not measured differences between the molecules

New England Journal of Medicine, 2022

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The problem: Ice crystal formation can damage peptide structure Potency loss Unproven benefit vs proven risk Better approach: Mix smaller batches more frequently Use within 28-30 days while refrigerated Mistake 4: Storing in fridge door The fridge door experiences the most temperature fluctuation