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These nutrient-based secretagogues include: Dietary lipids, especially triacylglycerol which is the primary fat found in foods Dietary carbohydrates, particularly those yielding glucose Short chain fatty acids (SCFAs) produced from fiber fermentation by gut microbes The high density of L-cells in the large intestine makes it a prime target for SCFA-mediated GLP-1 secretion

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doi: 10.3389/fphys.2022.886704 25 GaberySSalinasCGPaulsenSJAhnfelt-RnneJAlanentaloTBaqueroAFet al

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