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As a review in The Journal of Clinical Endocrinology & Metabolism describes, the warning specifically advises against these drugs for people with a personal or family history of medullary thyroid carcinoma or MEN2, a guidance rooted in rodent studies rather than common thyroid conditions

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Both formulas mimic GLP-1 receptor agonists, a naturally occurring substance that your gut secretes during digestion to create the sensation of fullness