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& Pang, J
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Understanding the hurdles the blood-brain barrier presents has helped us develop innovative solutions to bypass this barrier to offer new treatment possibilities safely
Importantly, evidence also shows that several polyphenols including EGCG, quercetin, curcumin and resveratrol modulate chromatin-remodeling enzymes such as DNMTs, HATs and HDACs, reinforcing their broad epigenetic impact beyond antioxidant and anti-inflammatory mechanisms ( In addition, polyphenols affect histone modifications, which regulate chromatin accessibility and transcriptional activity
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