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According to the protective mode, which characterizes the lifestyle of biofilm cells, our analyses revealed the overexpression of enzymes devoted to scavenging diverse ROS: catalase (BC3008), superoxide dismutases ( BC1468, BC4907 ), chloroperoxidase ( BC4774 ), alkylhydroperoxidase ( BC2830 ,), and glyoxalases ( BC5092*, BC3178, BC0824 )
This process is not necessarily irreversible
Similar underlying processes are indicated by other known risk loci for both PD and IBD, which include lysosomal dysfunction (e.g., GALC and GPR65) and immunological response and microbial induction (e.g., the HLA locus) (101)
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