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The clinical expert also noted that the definition of MACE used in PIONEER 6, which included CV death, non-fatal MI or non-fatal stroke, was relevant to clinical practice
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While mitochondria have their own antioxidant defenses, including mitochondrial SOD, these defenses are often insufficient to neutralize the high levels of ROS produced during oxidative phosphorylation, especially if mitochondrial function is compromised
Glucagon is not simply an adversary of weight-loss therapy
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