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doi: 10.1146/annurev-immunol-102119-073855 97 ZhaoSZhongYFuXWangYYePCaiJet al
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Research has demonstrated that PINK1 is an upstream regulator of Parkin, with both proteins synergistically mediating the polyubiquitination of structural or functional proteins on the surface of damaged mitochondria, playing a pivotal role in the autophagic degradation of depolarized mitochondria [26]
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