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Egan AG, Blind E, Dunder K, et al
The researchers optimized the potency ratio between the three receptors and used a protraction strategy that allows for once-weekly dosing, then tested the drugs in diet-induced obese mice
The demonstrated efficacy of LC in ameliorating myocardial energy metabolism remodeling in animal models, together with its established clinical profile, justifies conducting a Phase I clinical trial to evaluate its metabolic therapeutic potential in myocarditis patients, while maintaining TMAO monitoring during extended administration
At the time of this writing, liraglutide is the only GLP-1 RA with a labeled indication to reduce the risk of major adverse cardiovascular events (MACE), yet several other GLP-1 RAs have shown significant reduction in MACE, as summarized in Table 2
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