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In contrast, under oxidative stress NRF2 dissociates from KEAP1 and translocates to the nucleus, where it activates the downstream expression of antioxidative response element (ARE)-containing target genes, many of which have been shown to play a role in defending against ferroptosis [65, 66]
Since then, the biological functions of zinc have been increasingly elucidated, particularly at the cellular level, where it is critical for maintaining homeostasis and proper function 3,4
Toxicol Appl Pharmacol 243(3):340347 Ramalingam L, Menikdiwela K, LeMieux M, Dufour JM, Kaur G, Kalupahana N, Moustaid-Moussa N (2017) The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance
If you are also exploring other treatments, you might find it helpful to read about Retatrutide benefits to learn more about what this peptide can do
