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PMID: 9815028
b , Gold standard Fourier shell correlation (FSC) curves of two individual half maps indicating an average resolution of 3.3 at 0.143 FSC threshold
The glucose-dependent insulinotropic polypeptide receptor adds a second layer of metabolic regulation that amplifies fat oxidation, improves lipid metabolism, and appears to enhance the weight loss effects beyond what GLP-1 activation alone can achieve
(1) Controlled-Release PHEN/TPM in Severely Obese Adults (EQUIP) trial (obesity without comorbidities), (2) Controlled-Release Phentermine plus Topiramate Combination in Overweight and Obese Adults (CONQUER) trial (obesity with comorbidities), and (3) SEQUEL (2-year extension of CONQUER), were comprised of 7% of older adult participants across the trials, although the upper age limit was 70 [111,112,113]
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