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The mtDNA is more vulnerable to excessive ROS-related damage to biomolecules, such as DNA repair enzyme proteins, than nuclear DNA (112), which disrupts the ETC and ultimately induces dysregulation of mitochondrial OXPHOS (113)
The diagnosis of MASLD is based on the confirmed presence of hepatic steatosis, determined by imaging techniques or biopsy, in combination with cardiometabolic risk factors such as obesity (i.e., elevated body mass index BMI), hypertension, IR, or dyslipidemia, while excluding significant alcohol consumption [18]
Never stop or adjust prescribed medications without consulting your doctor, as this could compromise treatment efficacy or safety
By targeting fat storage mechanisms, Semaglutide helps prevent the accumulation of excess body fat, leading to more significant and sustained weight loss results
