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The effects of microbiome and its metabolites on body functions are complex, and in many studies we have found that the improvement of symptoms before and after treatment is accompanied by a certain change in the microbiome structure, a phenomenon that leads us to think further about the question of whether a drug is effective by targeting a certain stage of the physiological/pathological response directly, or whether a drug is effective by affecting certain signals through changes in the internal environment affecting the structure of the microbiome, or both

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In the US, individuals with overweight or obesity using GLP-1 RAs has increased from 21,000 in 2019 to 174,000 in 2023, which is a 700% increase in usage 11

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