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In SURMOUNT-2, the mean WL was up to 15.7% with tirzepatide 15 mg compared to 3.3% WL with placebo at 72 weeks for people with obesity and T2D [47]
Identifying risk factors is another important aspect
Notably, the substitution at position 8 reduces susceptibility to degradation by dipeptidyl peptidase-4 (DPP-4) (21, 22)
Over half of users said their GLP-1s were difficult to afford, and many who had stopped the treatment cited the cost
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