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This multi-receptor approach distinguishes it from existing licensed medicines such as semaglutide (Ozempic, Wegovy) or tirzepatide licensed in the UK as Mounjaro for type 2 diabetes and as Zepbound for obesity which act on fewer receptor pathways
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Unlike phosphodiesterase-5 (PDE5) inhibitors such as sildenafil or tadalafil, which directly enhance nitric oxide signaling in penile tissue, tirzepatide's primary targets are metabolic receptors in the pancreas, gastrointestinal tract, and brain
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