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Research proposes that while it may influence senescence-associated pathways, it appears to preserve FOXO4s antioxidative transcriptional activity
A similar pattern was observed in the SURMOUNT-4 trial for tirzepatide: after participants lost an average of 20.9% of their body weight during a 36-week lead-in phase, those who stopped treatment regained about 14%, while those who continued taking tirzepatide lost an additional 5.5% over the next year
Acknowledgements The authors acknowledge the efforts of Prof Omnia ElRashidy one of the founders of the Pediatric Ketoclinic and Prof Ehab Khairy Emam the Head of the Pediatric Gastroenterology, Hepatology and Clinical Nutrition Unit, at the children`s Hospital, Faculty of Medicine, Ain shams University, for their support
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