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To dissect the role of caspases in the observed profile, we included two inhibitors: Q-VD-OPh (referred to hereafter as QVD), a pan-caspase inhibitor targeting caspases 1, 3, 7, 8, 9, 10 and 12, and Ac-DEVD-CHO (referred to hereafter as DEVD), which selectively inhibits caspases 3, 6, 7, 8 and 10
IGF1 LR3 50-100
- Administration: Subcutaneous injection
On the one hand, cancer metabolism-related signals or metabolites affect the activation and function of microenvironmental antitumor immune cells (T cells and NK cells) in the TME, and on the other hand, cancer-associated stromal cells, such as CAFs, and immunosuppressive cells (M2 macrophages and MDSCs) reshape the local metabolic environment and oncogenic pathways, further promoting malignant tumor progression
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