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Maintenance and Long-Term Use: STEP-4 Trial: Participants who stopped semaglutide regained most weight Those who continued maintained loss and continued losing Suggests long-term treatment necessary for maintenance Most experts recommend: Treating obesity as chronic disease Long-term or indefinite medication use Transitioning to maintenance dose (not stopping) Combining with lifestyle changes for best results Understanding the complete comparison between semaglutide and tirzepatide helps determine which medication best fits your goals
Ensure you stay well-hydrated by drinking plenty of water throughout the day
4.10 SURMOUNT-1: tirzepatide for weight loss in obese adults In the SURMOUNT-1 trial, 2,539 adults with an average weight of 104.8 kg and an average BMI of 38.0 were treated with weekly doses of tirzepatide (5 mg, 10 mg, 15 mg) or placebo for 72 weeks
Several indirect mechanisms could theoretically link semaglutide use to RLS symptoms, though these remain entirely speculative
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