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Although preclinical studies link GLP-1 signaling to brown adipose tissue (BAT) activation and adipose tissue browning, human data indicate that BAT mass and thermogenic capacity in adulthoodparticularly in obesityare limited, constraining the contribution of energy expenditure to sustained weight loss
Where the peptides differ significantly is in their side effect profiles and titration timelines
For example, optimal levels of both diet and exercise increases bone mineralization during childhood, a critical period of growth and development, and lessens their risk of osteoporosis and bone fractures later in life
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